FLIX FLow chemistry for Isotopic eXchange

The ‘FLIX machinery’ will use a combination of specialized reactor modules operating under continuous flow conditions, either in closedloop or open systems for the on-line H/D, C-12/C-13, N-14/N-15 and methoxy group direct isotopic exchanges with an unprecedented efficacy and without any chemical alteration of the molecules.

The project’s objectives are to:

1) develop new generations of organometallic catalysts for isotopic exchange reactions;

2) screen catalysts for the isotopic exchange on a relevant portfolio of organic molecules in batch and flow chemistries and assess catalyst robustness;

3) devise and validate the ‘combinable isotope labeling’ concept;

4) design and build an adaptable multi-module machinery for combinable chemical exchange labeling.

FLIX synergistically associates the expertise and innovation potential of a mixed academic/industrial multidisciplinary consortium. The project is expected to have a multi-billion Euro positive impact on all sectors using stable isotopes in particular:

1) drug innovation, by accelerating preclinical studies, de-risking clinical trials and fostering the development of novel deuterated ‘heavy drugs’;

2) design of new tracers for diagnostic imaging with improved biological properties;

3) streamlining the production of multi-labeled complex molecules for NMR studies;

4) the development of novel isotopically-enriched materials.